| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15d42f684941d5b0617ca7764ebdff07 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-15 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4738
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y303-02009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4746
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate |
1997-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a9a6659047374613938f9b22bb4af51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_527c2c5d7eba710a23be48ec7d664695
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63004b23801105c9386376e4ec577379
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa89c7e60d653cd8154879efe243e442 |
| publicationDate |
1999-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0914338-A2 |
| titleOfInvention |
Cell growth regulatory genes |
| abstract |
Transcriptionally regulated growth-response genes play a pivotal role in the determination o a cell's fate. p53 is known to transcriptionally regulate genes important in regulating cell growth potential. Using differential RT-PCR analysis of rat embryo fibroblast cells containing a temperature-sensitive p53 allele, we were able to isolate several transcripts upregulated specifically in cells harboring the wild-type p53 protein. Two of these genes, SM20 and microsomal epoxide hydrolase (mEH), are previously described genes. Two previously uncharacterized cDNA's, cell growth regulatory (CGR) genes CGR11 and CGR19, were isolated. The predicted amino acid sequences of these novel proteins contain known motifs; EF-hand domains (CGR11) and a ring-finger domain (CGR19), are suggestive of function. CGR11 and CGR19 appear to be primary response genes expressed at 0.05 % and 0.01 % of the total mRNA in wild-type p53 cells. Both CGR11 and CGR19 as well as SM20 and mEH, are able to inhibit growth of several cell lines. |
| priorityDate |
1996-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |