http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0914332-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 |
| filingDate | 1997-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40ca5f3b1fdf78d6f5deb5b9f5164ec5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a91757ab74f96ca77e1f4a8bcd76fbef |
| publicationDate | 2002-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0914332-B1 |
| titleOfInvention | Isoquinolines useful as analgesics |
| abstract | PCT No. PCT/SE97/00315 Sec. 371 Date Oct. 6, 1997 Sec. 102(e) Date Oct. 6, 1997 PCT Filed Feb. 25, 1997 PCT Pub. No. WO97/31940 PCT Pub. Date Sep. 4, 1997The present invention is directed to compounds that act as analgesics and that have the structure of formula (I): wherein; Z is wherein, n is 1 or 2, and R0 is C6-12 aryl or C7-8 aralkyl; or R1 is selected from the group consisting of hydrogen; -NH-C1-6 alkyl; C1-6 alkyl; C6-12 aryl; C7-18 aralkyl; arginyl; and R30NHC(=NH)-, wherein R30 is hydrogen, C6-12 aryl, C7-18 aralkyl, or C1-6 alkyl; R2 is hydrogen; C1-6 alkyl; or OH; R3 is C6-12 aryl; C7-18 aralkyl; -CH2-C6H2R8R9;or -CH2-OHC6HR8R9, wherein each of R8 and R9 is independently, or hydrogen; R4 C6-12 aryl; C7-18 aralkyl; C1-12 alkyl; or a substituted or unsubstituted cyclohexyl; R5 is C1-6 alkyl; hydrogen; OH; halogen; SH; NO2; NH2; -NH-C1-6 alkyl; NH2C (=NH-; NH2C (=NH)-NH-; COOR31, wherein, R31 is hydrogen, or C1-6 alkyl; X is CH2NHC(O)-; CH2NHC(O)O; -C(O)NH-; or CH2NH-; and L is a C1-12 alkylene chain which can be substituted with at least one substituent selected from the group consisting of; a C3-C12 cycloalkyl containing at least one heteroatom; C1-6 alkyl; OR31; -NHC(O)R33; -OC(O)R34 -NHR35 wherein; and NR6R7; with the proviso that when R5 is hydrogen, Z is and X is -C(O)NH-, or -CH2NH-, then L is a C1-12 alkyl chain substituted with at least one substituent selected from the group consisting of; a C3-C12 cycloalkyl containing at least one heteroatom; C1-6 alkyl; OR31; SR32; -NHC(O)R33; -OC(O)R34, -NHR35; and NR6R7. |
| priorityDate | 1996-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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