http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0913186-A1

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filingDate 1997-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_302e5cc279f7dfb21da5747d1b43769e
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publicationDate 1999-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0913186-A1
titleOfInvention Hollow fiber membrane and method of manufacturing same
abstract There is disclosed a hollow fiber membrane withnexcellent substance-separating capability and superiornperformance for removal of high molecular weightnsubstances in blood, particularly β 2 microglobulinn(molecular weight: 11,800 daltons) when used fornhemodialysis, while preventing penetration of endotoxinnfragments from the dialyzing solution into the bodies ofnpatients, and exhibiting excellent biocompatibility. Thenhollow fiber membrane is characterized by having a waterntransmissivity of 30-300 ml/m 2 ·hr·mmHg and a membranenthickness of 5-50 µm, by having a pore size D 1 on theninner wall surface such that 10 ≤ D 1 ≤ 300 nm, a porensize D 2 on the outer wall surface such that 0.6 D 1 ≤ D 2 ≤n1.2 D 1 and a pore size D 3 inside the membrane such that D 3 n≥ 1.2 D 1 , wherein the pore size increases in a continuousnmanner from the inner wall surface toward the interior ofnthe membrane while decreasing in a continuous manner fromnthe interior of the membrane toward the outer wallnsurface, at least one maximum size area is present in theninterior of the membrane, and the inner wall layer porensize increase rate (ρ 1 ) and outer wall layer pore sizendecrease rate (ρ 2 ) are each 20-200% n The hollow fiber membrane of the invention isnmanufactured by discharging a spinning solutionncomprising a polymer and a polymer solvent from the outernspinning aperture of a double annular spinning nozzlenwhile discharging a hollow-forming agent from the innernspinning aperture, and coagulating the spinning solutionnin a coagulating bath of at least two stages comprising ansolution which gives a higher coagulation speed thannwater.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0923984-A4
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010144057-A1
priorityDate 1997-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 39.