| abstract |
The invention concerns a compound of formula (I), wherein, for example: R<1> is of the formula -NHC(=O)(1-4C)alkyl; R<2> and R<3> are hydrogen or fluoro; R<4> and R<5> are hydrogen or methyl; >A-B- is of the formula >C=CH-, >CHCH2, or >C(OH)CH2- (> represents two single bonds); D is O, S, SO, SO2 or -NR<7>; wherein R<7> is hydrogen, R<10>CO-, R<10>SO2-, R<a>OC(R<b>)=CH(C=O)-, R<c>C(=O)C(=O)-, R<d>N=C(R<e>)C(=O)-, R<f>NHC(R<g>)=CHC(=O)- or R<14>CH(R<13>)(CH2)m-; wherein R<10> is (1-6C)alkyl [optionally substituted by, for example, hydroxy or (1-6C)alkanoyl], R<11>C(O)O(1-6C)alkyl or R<12>O-; wherein R <11> is optionally substituted (1-6C)alkyl; R<12> is optionally substituted (1-6C)alkyl; R<a>, R<b>, R<c>, R<d>, R<e>, R<f>, R<g> are (1-6C)alkyl; m is 0 or 1; R<13> is cyano; R<14> is hydrogen or (1-4C)alkyl; >X-Y- is of the formula >C=CH- or >CHCH2-; and pharmaceutically acceptable salts thereof; processes for the preparation; pharmaceutical compositions containing them and their use as antibacterial agents. |