| abstract |
The invention relates to compounds of formula (I), wherein: R2 represents hydroxy, halogeno, C¿1-3?alkyl, C1-3alkoxy, C1-3alkanoyloxy, trifluoromethyl, cyano, amino, nitro, C2-4alkanoyl, C1-4alkanoylamino, C1-4alkoxycarbonyl, C1-4alkylthio, C1-4alkylsulphinyl, C1-4alkylsulphonyl, carbamoyl, N-C1-4alkylcarbamoyl, N,N-di(C1-4alkyl)carbamoyl, aminosulphonyl, N-C1-4alkylaminosulphonyl, N,N-di(C1-4)alkyl)aminosulphonyl, C1-4alkylsulphonylamino, or a group R?4X1¿ wherein X1 represents a direct bond, C¿2-4?alkanoyl, -CONR?5R6¿-, -SO¿2NR?7R8- or -SO¿2R?9- (wherein R?5 and R7¿, each independently represents hydrogen or C¿1-2?alkyl and R?6, R8 and R9¿ each independently represents C¿1-4?alkyl and wherein R?4¿ is linked to R?6, R8 or R9) and R4¿ represents an optionally substituted group selected from phenyl and a 5 or 6-membered heterocyclic group; n is an integer from 0 to 4; R1 represents hydrogen, C¿1-4?alkyl, C1-4alkoxymethyl, di(C1-4alkoxy)methyl or C1-4alkanoyl; m is an integer from 0 to 4; and R?3¿ represents hydroxy, halogeno, nitro, trifluoromethyl, C¿1-3?alkyl, cyano, amino or R?10X2¿ (wherein X2 represents a direct bond, -CH¿2?-, or a single or double heteroatom linker group including -S-, -SO- and -NR?15¿- (wherein R15 represents hydrogen, C¿1-3?alkyl or C1-3alkoxyC2-3alkyl), and R?10¿ is an alkenyl or alkynyl chain optionally substituted by for example hydroxy, amino, nitro, alkyl, cycloalkyl, alkoxyalkyl, or an optionally substituted group selected from pyridone, phenyl and a heterocyclic ring, which alkyl, alkenyl or alkynyl chain may have a heteroatom linker group, or R10 is an optionally substituted group selected from pyridone, phenyl and a heterocyclic ring. The compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF and FGF, properties of value in the treatment of a number of disease states including cancer and rheumatoid arthritis. |