abstract |
A method of increasing sphincter competence comprising administering to a human in need of treatment an effective amount of a compound having formula (I), wherein R?1 and R3¿ are independently hydrogen, -CH¿3?, (a) or (b), wherein Ar is optionally substituted phenyl; R?2¿ is selected from the group consisting of pyrrolidino, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof. Also encompassed by the invention is a method of inhibiting urinary or fecal incontinence, or gastroesophageal disease or its symptoms, which includes administering to a human in need thereof an effective amount of a compound of formula (I). |