http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0906308-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 |
| filingDate | 1997-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6ebbbc35f3a8e599c65f44841c3c4c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16f482ff7a65c6dd909b6458ff4e4a0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f7c2f7cc8bf7d236379ccf50dcc6e2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ea117a3d1498dd06fdb65e4fb38136c |
| publicationDate | 1999-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0906308-A1 |
| titleOfInvention | Azetidine, pyrrolidine and piperidine derivatives as 5-ht1d receptor agonists |
| abstract | A class of substituted azetidine, pyrrolidine and piperidine derivatives of formula (I) are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5-HT1Dα receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT1Dα receptor subtype relative to the 5-HT1Dβ subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists, wherein Z represents an optionally substituted six-membered heteroaromatic ring selected from pyridine, pyrazine, pyrimidine and pyridazine; E represents a chemical bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms; Q represents a straight or branched alkylene chain containing from 1 to 4 carbon atoms, optionally substituted in any position by one or more substituents selected from fluoro and hydroxy; T represents nitrogen or CH; U represents N or CR2. V = O, S or NR3. M & R are as defined in the application. |
| priorityDate | 1996-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 791.