| abstract |
Compounds of general formula (1) are described, wherein Ar is an optionally substituted aromatic or heteroaromatic group; X1 is an oxygen or sulphur atom; R1 is a hydrogen atom or a methyl group; R2 is a hydrogen atom or a group -Alk?1 or -X2Alk1¿ where Alk1 is an optionally substituted aliphatic or heteroaliphatic group and X2 is a -C(O)-, -C(S)-, or -S(O)¿n? group where n is an integer 1 or 2; R?3¿ is a hydrogen atom or a group -Alk2, [where Alk2 is as defined for Alk?1], -X2Alk2, -Ar1¿ [where Ar1 is an optionally substituted aromatic or heteroaromatic group], -Alk?2Ar1, or -X2Alk2Ar1¿; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective inhibitors of the protein tyrosine kinase p56Ick and are of use in the prophylaxis and treatement of immune diseases, hyperproliferative disorders and other diseases in which inappropriate p56Ick activity is believed to have a role. |