| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac73e460fd686a7a694d3a0a81b03c74 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-335 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate |
1996-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc7cd6ecf0b2bfe409648205705ef07a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fcdad0053a73d124a2eb7bf9fa8db54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_971123d164981ef3e436f148fd8adfb2 |
| publicationDate |
2002-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0902783-B1 |
| titleOfInvention |
Hydrolysis-promoting taxane hydrophobic derivatives |
| abstract |
Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysis-promoting group" ("HPG"). Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers. |
| priorityDate |
1995-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |