| abstract |
The present invention relates to an isosorbide dinitrate-containingnpatch, in which an adhesive layer comprising an adhesivencomposition is formed on a flexible support, and the adhesivencomposition consists of an acrylic-based adhesive (A), a polyvinylnacetate-based adhesive (B), a plasticizing component (C) andnisosorbide dinitrate (D), and satisfies the following weight ratios (1)nthrough (3) of each of the components:n (1) A:B = 70:30 to 10:90, (2) the weight ratio of the component C based on the adhesivencomposition is 10 to 40% by weight, and (3) the weight ratio of the component D based on the adhesivencomposition is 20 to 35% by weight. n Provided is a patch excellent in percutaneous absorption,nhandleability, resistance to skin irritation, sustained release,nadhesivity, etc. |