| abstract |
The invention relates to the use of tetrahydrofolates in naturalnstereoisomeric form suitable for the preparation of a pharmaceutical preparationnto influence the homocysteine level, in particular to support thenRemethylation of homocysteine. Clinical areas of application are allnAnomalies in homocysteine levels, but especially prevention and treatmentnof cardiovascular diseases and the prevention of neural tube defects.n n n The invention also relates to pharmaceutical preparations containing at leastna compound selected from the group consisting of 5-formyl- (6S) -tetrahydrofolic acid,n5-methyl- (6S) -tetrahydrofolic acid, 5,10-methylene- (6R) -tetrahydrofolic acid,n5,10-methenyl- (6R) -tetrahydrofolic acid, 10-formyl- (6R) -tetrahydrofolic acid,n5-Formimino- (6S) -tetrahydrofolic acid or (6S) -tetrahydrofolic acid or their pharmaceuticalncompatible salts, together with pharmaceutically acceptable active andnExcipients, to influence the homocysteine level, especially if there is onenMethylene tetrahydrofolate reductase deficiency such as B. with existingnthermolabile methylene tetrahydrofolate reductase. |