| abstract |
Novel compounds show high affinity for specific cocainenreceptors in the brain, particularly dopamine transporternsites, and have the formulan nWhereinn Y = CO 2 R 2 , R 1 = hydrogen, C 1-5 alkyl, R 2 = hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl, C 1-4 alkoxy, C 1-6 nalkynyl, halogen or amine, R 3 = OH, hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl, C 1-4 alkoxy, Cl,nBr, I, CN, NH 2 , NHC 1-6 alkyl, NC 1-6 alkyl, OCOC 1-6 alkyl,nOCOC 1-3 alkylaryl, A = S, O or NH X = C 1-6 alkyl, C 3-8 cycloalkyl, C 1-4 alkoxy, C 1-6 alkynyl,nhalogen, amino, acylamido, nand Z = I, Br, Cl, F, CN, CF 3 NO 2 , N 3 , OR 1 , CO 2 NH 2 , CO 2 R 1 , C 1-6 nalkyl, NR 4 R 5 , NHCOR 5 , NHCO 2 R 6 , nwherein R 4 -R 6 are each C 1-6 alkyl and wherein said compoundnbears at least one iodine or carbon atom which is radioactive. |