| abstract |
A class of substituted benzylnaphthylene compounds ofnthe structuren nwhere R 1 and R 2 are independently hydrogen, alkyl of one tonsix carbon atoms, acyl of two to six carbon atoms, ornphenacyl; X is -(CH 2 ) 1-6 ; Y is absent or is selected fromn1,4-piperazinylene; ureido; N-(lower alkyl)ureido; N'-(lowernalkyl)ureido; or N, N'-(di-lower alkyl ureido; and Z is 1-,n2- or 3-pyrrolidinyl; 1-, 2-, or 3-[1-(lower alkyl)npyrrolidinyl]; 1- 2-,3- or 4-piperidinyl; 1-, 2-, 3- or 4-[1-lowernalkyl)piperidinyl]; N,N-dialkyl; 1-azepinyl; 1- orn2-naphthylamino, 4-morpholinyl, dimethyl-4-morpholinyl, 3-azaspiro[5.5]undecan-3-yl;npyrrolidinon-1-yl; unsubstitutednphenyl; or phenyl substituted with acyl of two to fourncarbon atoms, alkyl of one to four carbon atoms, halo, ornalkoxy of one to four carbon atoms; with the proviso that nnis not 2 or 3 when Z is 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl,n4-morpholinyl, N,N-dimethylamino or N,N-diethylamino;nare selective estrogen receptor modulators useful innthe prophylaxis or treatment of breast cancer. |