| abstract |
The present invention relates to a neovascularizationninhibitor comprising as an active ingredient N-(3,4-dimethoxycinnamoyl)nanthranilic acid represented by the formula:n nor a pharmaceutically acceptable salt thereof, which hasninhibitory effects on proliferation and chemotaxis of humannmicrovascular endothelial cells and tube formation of humannmicrovascular endothelial cells, and therefore, is useful as annagent for the prevention and treatment of diseases associatednwith neovascularization such as diabetic retinopathy, senilendiscoid macular degeneration, neovascular glaucoma and rheumaticnarthritis. |