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filingDate 1998-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2006-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecb8d531f3deb40efdfe5a3271d93bef
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publicationDate 2006-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0892054-B1
titleOfInvention Clostridium perfringens vaccine
abstract The present invention relates to detoxified immunogenic derivatives of Clostridium perfringens beta -toxin or an immunogenic fragment thereof that have as a characteristic that they carry a mutation in the beta -toxin amino acid sequence, not found in the wild-type beta -toxin amino acid sequence. The invention also relates to genes encoding such beta -toxins, as well as to expression systems expressing such beta -toxins. Moreover, the invention relates to bacterial expression systems expressing a native beta -toxin. Finally, the invention relates to vaccines based upon detoxified immunogenic derivatives of Clostridium perfringens beta -toxin, and methods for the preparation of such vaccines.
priorityDate 1997-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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