| abstract |
The invention is concerned with compounds of the general formulan nwhereinn R 1 signifies hydrogen, lower alkyl, phenyl or benzyl, R 2 signifies lower alkyl, lower alkoxy, -O(CH 2 ) n N(R 13 )(R 14 ),n-(CH 2 ) n N(R 13 )(R 14 ) or -N(R 15 )(CH 2 ) n N(R 13 )(R 14 ), R 3 -R 12 signify hydrogen, halogen, trifluoromethyl, lower alkyl, cycloalkyl,nlower alkoxy, hydroxy, nitro, cyano, -N(R 13 ) 2 , phenyl, phenyloxy,nbenzyl or benzyloxy, or R 6 and R 7 together signify a benzene ring, R 13 -R 15 signify hydrogen, lower alkyl or cycloalkyl and n signifies 1-5, nas well as their pharmaceutically acceptable salts.n These compounds are suitable for the control or prevention of acute and/or chronicnneurological disorders such as restricted brain function caused by bypass operations orntransplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxiancaused by pregnancy, cardiac arrest, hypoglycaemia, Alzheimer's disease,Huntington'snchorea, ALS, dementia caused by AIDS, eye injuries, retinopathy, cognitive disorders,nidiopathic parkinsonism or parkinsonism caused by medicaments as well as conditionsnwhich lead to glutamate-deficiency functions, such as e.g. muscle spasms, convulsions,nmigraine, urinary incontinence, nicotine addiction, psychoses, opiate addiction, anxiety,nvomiting, chronic pain, dyskinesia and depressions. |