http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0890571-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e83d93ed02bbd6159e99b5a7796e3686 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C219-24 |
| filingDate | 1998-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30148f694468e5ee63b3be1f7ad5a027 |
| publicationDate | 1999-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0890571-A1 |
| titleOfInvention | Process for the preparation of(1S,2R)-1-amino-2-indanol-(R,R)-tartrate methanol solvate |
| abstract | Process for the preparation of (1S,2R)-1-amino-2-indanol-(R,R)-tartratenmethanol solvate, in which in ansolvent a mixture of enantiomers of cis-1-amino-2-indanolnreacts at an elevated temperature with (R,R)-tartaric acidnand methanol and in which optically enriched (1S,2R)-1-amino-2-indanol-(R,R)-tartratenmethanol solvatencrystallizes out, after which the crystals are recovered,nthe recovery taking place at a temperature between 10 andn50°C in the presence of 0-20 wt.% water relative to thenamount of methanol plus solvent, on the understanding thatnif the reaction mixture is essentially free from water thenrecovery substantially takes place at a temperaturenbetween 30 and 50°C. Preferably the reactants are at leastnin part contacted with each other at an elevatedntemperature and only methanol is used as solvent.nPreferably the amount of (1S,2R)-1-amino-2-indanol appliednis between 0.02 and 0.1 g per ml of solvent. n The invention also relates to (1S,2R)-1-amino-2-indanol-(R,R)-tartratenmethanol solvate crystals having anparticle size larger than 95 µm, expressed as D[v, 0.9],nin particular those in which the enantiomeric excess ofn(1S,2R)-1-amino-2-indanol-(R,R)-tartrate relative ton(1R,2S)-1-amino-2-indanol-(R,R)-tartrate is higher thann96%, as well as to application of (1S,2R)-1-amino-2-indanol-(R,R)-tartratenmethanol solvate in the preparationnof AIDS inhibitors, in particular indinavir sulphate. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7544841-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2891647-A4 |
| priorityDate | 1997-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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