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filingDate 1996-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f98ba1185cc67028275a592702c0e8f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_118d6bd9436f381ded7817c788fc1a8a
publicationDate 1999-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0888381-A1
titleOfInvention Targeted therapeutic or diagnostic agents and methods of making and using same
abstract The present invention provides a targeted therapeutic or diagnostic agent comprising (a) a therapeutic or diagnostic functional entity linked to one of the following: (a) an isolated peptide mimetic that specifically binds a selected target; (b) an isolated, optimized, high-affinity polyamino acid that specifically binds a selected target; (c) an isolated protein surface loop that specifically binds a selected target, wherein the protein surface loop is not endogenous to the functional entity. The invention additionally provides methods of targeting therapeutic or diagnostic agents to a target. Additionally provided is a method of targeting a therapeutic agent to a platelet using the present agents, and methods of treating diseases and disorders associated with blood clots. Specifically provided is a recombinant targeting protein wherein the surface loop is the HCDR3 of monoclonal antibody Fab-9, the second protein is human tissue type plasminogen activator (t-PA), and the target is platelet glycoprotein GPIIb/IIIa (integrin αIIbβI).
priorityDate 1995-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID18815
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID9704319
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID114423
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP83169
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID60545135
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5554
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID396985
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP15120
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID8617806
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID1148
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP15057
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5RF29
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3169327
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID232
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID563084
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID12207008

Total number of triples: 327.