http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0886634-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e93d357c3fcb571238ff08afe6072cd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-46 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-46 |
| filingDate | 1997-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2cfbed0bd9952e525d58d44c8669dd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f006b25fb28b1b91005a8104583fea86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dfde8d1bd55b0d84233cba81a27ef06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9968cdc1890e9fcda97dd3f71e1a4816 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2e2cadc40e8aa8ea87a97ce87b35fd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58d49d0445c1115fad33607023d64a1c |
| publicationDate | 1998-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0886634-A1 |
| titleOfInvention | Process for producing ioversol |
| abstract | The present invention discloses a new process for producing ioversol (marketed as OPTIRAY(R)) comprising:(a) reacting 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisopthalamide with chloroacetyl chloride in a polar aprotic solvent or combinations thereof to produce N,N'-bis[2,3-di(2-chloroacetoxy)propyl]-5-(2-chloroacetamido)-2,4,6-triiodoisophthalamide;(b) reacting the product of (a) with a base to produce N,N'-bis(2,3-dihydroxypropyl)-5-(2-chloroacetamido)-2,4,6-triiodoisopthalamide;(c) reacting the product of (b) with an alkylating agent capable of producing a hydroxyethylated product in the presence of a base and water to produce N,N'-bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl) (2-chloroacetamido)]-2,4,6-triiodoisopthalamide; and(d) reacting the product of (c) in water and acetate ions to produce ioversol. |
| priorityDate | 1996-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.