| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82b460ae2c0d553a2db7abd984e85631 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-18 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02 |
| filingDate |
1992-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dce298a6ad41d7e767d3bc51b5132df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1fecf69d802915fb05d4c13a08cd5f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a6b49cd43bdf3b24e1ba5bec3f88374 |
| publicationDate |
1998-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0885900-A2 |
| titleOfInvention |
Increasing blood-brain barrier permeability with permeabilizer peptide derivatives of bradykinin |
| abstract |
Peptides called receptor mediated permeabilizers (RMP)nincrease the permeability of the blood/brain barrier tonmolecules such as therapeutic agents or diagnostic agents.nThe permeabilizer A-7 or conformational analogues can benintravenously coadministered to a host together withnmolecules whose desired destination is the interstitialnfluid compartment of the brain. Alternatively, thenpermeabilizer A-7 or conformational analogues can benadministered sequentially with the molecule(s) of interestnand these molecules can also be administered by routesnother than intravascular. The permeabilizer A-7 ornconformational analogues allow these molecules to penetratenthe blood-brain barrier and arrive in the interstitialnfluid. |
| priorityDate |
1991-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |