| abstract |
The present invention relates to novel quinazolin-4-one derivatives of thenformula I,n nwherein A is a benzo or thieno fused aromatic ring;n B is phenyl, pyridyl or pyrimidyl; X is N or CH; Y and Z, taken together, i.e. , Y-Z, are eithern-CH 2 NH- or -NHCH 2 -; R 1 is selected from hydrogen,n(C 1 -C 6 )alkyl optionally substituted with from one tonthree fluorine atoms, cyano, halo, amino, nitro andn(C 1 -C 6 )alkoxy optionally substituted with from one tonthree fluorine atoms; R 2 is halo, cyano, (C 1 -C 6 )alkyl optionallynsubstituted with from one to three fluorine atoms, nitro, amino,n(C 1 -C 6 )alkylthio, (C 1 -C 6 )alkoxynoptionally substituted with from one to three fluorine atoms, hydroxy,nH-C(=O)-, (C 1 -C 6 )alkyl-O-C(=O)- ornNH 2 -C(=O)-; R 3 and R 4 are selected, independently, fromnhydrogen, (C 1 -C 6 )alkyl optionally substituted withnfrom one to three fluorine atoms, halo, cyano, hydroxyn(C 1 -C 6 )alkoxy optionally substituted with from one tonthree fluorine atoms, -C(=O)H, -CH 2 OR 5 andn-CH 2 NR 6 R 7 ; npharmaceutical compositions containingnsuch compounds the use of such compounds to treat neurodegenerative,npsychotropic, and drug and alcohol induced central and peripheral nervous systemndisorders. |