abstract |
The invention relates to a new method of preparing 16-dehydro vitaminnD compounds having formula In nwherein:n R has the epi-configuration or the normal configuration and representsnstraight or branched C 1-6 -alkyl, C 2-6 -alkenyl, C 3-6 -cycloalkyl, or annaromatic group optionally substituted with halogen, C 1-3 -alkyl or alkoxy, Z is a saturated or unsaturated straight hydrocarbon group ornoxahydrocarbon group containing 3-6 C-atoms which may bensubstituted with OH, F, alkyl (C 1-3 ) or cycloalkyl (C 3-5 ), R 1 is hydrogen or an hydroxy protecting group, R 2 is hydrogen or hydroxy, and A and B represent hydrogen or methyl, or together form the methylenengroup, to the new compounds having this formula and to newnintermediates obtainable according to this process. |