| abstract |
This invention provides novel indenone derivatives,ntheir pharmaceutical formulations and their use for theninhibition of leukocyte adherence to cells. The indenonenderivative is of the formulan nwhere R 1 and R 2 are each independently hydrogen, hydroxy,nnitro, amino, C 1 -C 4 alkyl, C 1 -C 4 alkoxy or halo;n R 3 is hydrogen, hydroxy, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 nalkynyl, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, halo, halo (C 1 -C 6 nalkyl), unsubstituted or substituted phenyl; and R 4 is hydrogen or C 1 -C 4 alkyl, or a pharmaceuticallynacceptable salt or solvate thereof; provided that, n when R 1 , R 2 and R 4 are each hydrogen, R 3 is othernthan C 1 -C 4 alkyl, halo(C 1 -C 4 alkyl), cyclopropylnor phenyl. |