| abstract |
The present invention relates to compounds of formula (I), wherein R represents hydroxy, C1-6alkoxy, C3-6alkenyloxy, C3-6alkynyloxy, fluoro C1-6alkoxy, C3-7cycloalkoxy, C3-7cycloalkylC1-4alkoxy, phenoxy, benzyloxy or halogen, wherein the phenyl moiety of said phenoxy or benzyloxy is optionally substituted by one, two or three of C1-6alkyl, C1-6alkoxy, halogen and trifluoromethyl; R?1, R2, R3, R4, R5, R6, R9a and R9b¿ are as defined in the specification; or R and R1 may be joined such that -R-R1- is a linkage selected from -O-CH¿2?- and -O-CH2CH2-; m is zero, 1, 2 or 3; and n is zero, 1, 2 or 3; with the proviso that the sum total of m and n is 2 or 3; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia. |