| abstract |
The present invention of compounds of formula (I), a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R1 is C¿1-6?alkyloxy, C2-6alkenyloxy or C2-6alkynyloxy; R?2¿ is hydrogen or C¿1-6?alkyloxy, or when taken together R?1 and R2¿ may form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C¿1-6?alkyl; R?3¿ is hydrogen or halo; R4 is hydrogen or C¿1-6?alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl optionally substituted with aryl, or L is a radical of formula -Alk-R?5¿-, Alk-X-R6, -Alk-Y-C(=O)-R8, or -Alk-Y-C(=O)-NR10R11 wherein each Alk is C¿1-12?alkanediyl; and R?5¿ is hydrogen, cyano, C¿1-6?alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, aryl, di(aryl)methyl or a heterocyclic ringsystem; R?6¿ is hydrogen, C¿1-6?alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, aryl or heterocyclic ringsystem; X is O, S, SO2 or NR?7¿; said R¿7? being hydrogen, C1-6alkyl or aryl; R?8¿ is hydrogen, C¿1-6?alkyl, C3-6cycloalkyl, aryl, arylC1-6alkyl, di(aryl)methyl, C1-6alkyloxy or hydroxy; Y is NR?9¿ or a direct bond; said R9 being hydrogen, C¿1-6?alkyl or aryl; R?10 and R11¿ each independently are hydrogen, C¿1-6?alkyl, C3-6cycloalkyl, aryl or arylC1-6alkyl, or R?10 and R11¿ combined with the nitrogen atom bearing R?10 and R11¿ may form a pyrrolidinyl or piperidinyl ring both being optionally substituted with C¿1-6?alkyl, amino or mono or di(C1-6alkyl)amino, or said R?10 and R11¿ combined with the nitrogen bearing R?10 and R11¿ may form a piperazinyl or 4-morpholinyl radical both being optionally substituted with C¿1-6?alkyl. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying. |