| abstract |
The invention relates to a method of preparing a compound of the generalnformulan fac -[M(CO) 3 (OH 2 ) 3 ] + n wherein M is Mn, 99m Tc, 186 Re or 188 Re, nby reacting a metal in the permetallate form with carbon monoxide and anreducing agent, characterized in that a mixture of a base, a reducing agentnsoluble in water but not substantially decomposed by water, and optionally anstabilizing agent is solved in a water containing solvent system containing ansolution of the metal in the permanganate, pertechnetate or perrhenate form innthe presence of carbon monoxide and optionally in the presence of a halide.nThe invention further relates to a method of preparing a labelled compoundnwith the aid of the compound of general formula I, to a method of directnpreparation of labeled compounds, to a method of labeling of substrates suchnas amino acids, peptides, proteins, sugars, small receptor binding moleculesnand body cells with the aid of compound of general formal I and to a kit for thenpreparation of a labelling composition and a kit for the preparation of andiagnostic of therapeutic pharmaceutical composition. |