| abstract |
The present invention provides a process for preparingna class of compounds having the structuren nwherein:n n is 0, 1, or 2; R is hydrogen or C 1 -C 4 alkyl; X 1 is hydrogen, cyano, 4-hydroxybenzoyl, 4-halobenzoyl,nor 4-(C 1 -C 4 alkoxy)benzoyl; Y is NR 4 R 5 , 4-hydroxyphenyl, or 4-(C 1 -C 4 alkoxy)phenyl; R 4 and R 5 are independently hydrogen ornC 1 -C 4 alkyl. n The compounds are useful intermediates in thenpreparation of a class of compounds including the selectivenestrogen receptor modulating compound 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[ b ]-thiophenen(raloxifene). |