| abstract |
Novel benzazepine derivative of formula (1) wherein R1 is H or halogen, A is lower alkylene, R?2 and R3¿ are the same or different and each H, lower alkoxy, lower alkyl having optionally a lower alkoxy substituent, etc., or R?2 and R3¿ may combine together with the nitrogen to which they bond to form a 5- to 7-membered saturated heterocyclic group which may optionally be substituted by a lower alkyl, etc., R4 is H, lower alkyl, OH, etc., R5 is -NHR6 (R6 is lower alkyl) or pyrrolidinyl, or a salt thereof, which show excellent anti-vasopressin activity, oxytocin antagonistic activity and vasopressin agonistic activity, and are useful as a vasopressin antagonist, a vasopressin agonist and an oxytocin antagonist. |