http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0874804-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_550f24cd12485038f5bf231a3d58694c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27 |
| filingDate | 1996-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd76c18d6649f0b6ac7d94932f1f44f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9c9f845a53762e37e5d52a528e324a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a790ccaa5eb51e64333651864da1753 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95a1c354b1d81be9080f56679a90ce43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddf9c0454987da4eda29d4cf47da6905 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c166a3bad72b82b1f7d346ac9dff970b |
| publicationDate | 1998-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0874804-A1 |
| titleOfInvention | A process for the optical resolution of 3-(p-chlorophenyl)-glutaramide |
| abstract | A process for the optical resolution of racemic 3-(p-chlorophenyl)-glutaramide (GAM) into its R isomer R-COOH and its S isomer S-COOH, which process includes the steps of either: (1) reacting racemic 3-(p-chlorophenyl)-glutaramide dissolved in a suitable solvent with S-(-)-α-methylbenzylamine of the formula H2N-S'; (2) precipitating out of the solution of step (1) R-CO2-.H3+N-S'; (3) dissolving the precipitate of step (2) in water, with the addition of a suitable acid; and (4) precipitating out of the solution of step (3) R-COOH; or (5) reacting racemic -3-(p-chlorophenyl)-glutaramide dissolved in a suitable solvent with R-(+)-α-methylbenzylamine of the formula H¿2?N-R'; (6) precipitating out of the solution of step (5) S-CO2?-.H¿3+N-R'; (7) dissolving the precipitate of step (6) in water, with the addition of a suitable acid; and (8) precipitating out of the solution of step (7) S-COOH. The R isomer of GAM may be used for the production of R-baclofen and the S isomer of GAM may be used for the production of S-baclofen. |
| priorityDate | 1995-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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