http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0871431-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcff13f8573db698307f919e6385d5c4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S516-923 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S516-93 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1217 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0461 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 |
| filingDate | 1995-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_532f073283eb726caf582d174e543773 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f7eb37b09e951b60a2c5d59e6c0d2ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba2d163d3261a54c1eb1e823d7a0c7cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca523f7d8e5b767f93d31f20ad2671aa |
| publicationDate | 2005-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0871431-B1 |
| titleOfInvention | Hepatocyte-selective oil-in-water emulsion |
| abstract | PCT No. PCT/US95/05974 Sec. 371 Date Nov. 15, 1996 Sec. 102(e) Date Nov. 15, 1996 PCT Filed May 16, 1995 PCT Pub. No. WO95/31181 PCT Pub. Date Nov. 23, 1995A heat and shelf-stable oil-in-water emulsion useful as a tissue or cell-selective delivery vehicle. Radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino-2,4,6-triiodophenyl)heptanoate] or 2-oleoylglycerol-1,3-bis[ omega -(3,5-bis-trifluoromethyl)-heptanoate] or phenyl acetate, can be incorporated into the lipophilic core of a lipoprotein-like emulsion particle. The lipophilic core is surrounded by a phospholipid membrane comprising cholesterol and apolipoproteins. For hepatocyte-selective delivery, the emulsion is chylomicron remnant-like by being in a size range of 50 to 200 nm as measured by number weighting analysis with a narrow size distribution (<2% greater than 300 nm) and having a composition simulating naturally-occurring chylomicron remnants. Use of cholesterol in the emulsion formula facilitates association of apolipoproteins, especially Apo E which are recognized by liver cells and necessary for binding and uptake. Stability and size constraints can be achieved by ultra high energy mixing equipment, such as the MicroFluidizer (Microfluidics Corp., Newton, Mass.) to form the emulsion. In preferred embodiments, osmolality of the emulsion is controlled by glycerol rather than normal saline. |
| priorityDate | 1994-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 319.