| abstract |
The invention relates to fluoro-substituted adamantane derivatives of the formula <CHEM> and to pharmaceutically acceptable salts thereof, wherein R<1>, R<2>, R<3>, and R<4> are as defined herein. The invention also relates to methods of treating neurological disorders, such as memory loss and Parkinson's disease, and bacterial and viral infections, through administration of a therapeutically effective amount of a compound of formula I. The invention also relates to a method of increasing the metabolic stability of an adamantane-containing pharmaceutical compound by incorporating a fluoro substituent on at least one bridge-head carbon of the adamantyl group of said adamantane-containing pharmaceutical compound. |