| abstract |
Three chemokines, RANTES, MIP-1 alpha and MIP-1 beta , are produced and secreted by several cell types, including CD8 positive lymphocytes, and act as HIV Suppressive Factors (SF). The identification of these substances as factors responsible for restricting HIV proliferation implicates their use, the use of analogs, and the use of respective genes, in the diagnosis, treatment and prevention of AIDS and other retrovirus-induced diseases. |