| abstract |
Benzoylguanidines of the formula I <IMAGE> in which: R (1) CF3; one of the substituents R (2) and R (3) is hydrogen; and the other substituent R (2) or R (3) -C (OH) (CH3) -CH2OH, -CH (CH3) -CH2OH or -C (OH) (CH3) 2; R (4) methyl, methoxy, Cl or DF3; and their pharmaceutically acceptable salts are suitable as antiarrhythmic drugs with cardioprotective components for the prevention of infarction and the treatment of infarction, as well as for the treatment of angina pectoris. They also preventively inhibit the pathophysiological processes when ischemically induced damage occurs, particularly when triggering ischemically induced cardiac arrhythmias. |