| abstract |
A vascular permeability suppressant includes annoxaspirooctane derivative of the general formula (I):n n[wherein, R 1 represents, for example, lower alkylcarbamoylngroup or protected carbamoyl group, R 2 represents lowernalkoxyl group, and R 3 represents nthe formulan nor a pharmaceutically acceptable salt thereof, together with anpharmaceutically acceptable carrier. Particularly, fornexample, an agent that can prevent retention ofncarcinomatous pleural effusion or carcinomatous ascites. |