| abstract |
Process for producing solid pharmaceutical dosage forms having at least two phases and comprising at least one polymeric binder and at least one drug comprises shaping a molten mixture of a polymeric binder (binder A) and optionally at least one drug and incorporating at least one solid preparation, optionally containing at least one drug, into the mixture in the course of shaping while the mixture is still plastic. Also claimed is a dosage form as above. Preferably the solid preparation is a solidified drug-containing melt of a polymeric binder (binder B), or a solidified drug melt, or a tablet, pill, pellet or drug crystal. Binder B is preferably an alkyl cellulose, hydroxyalkyl cellulose, carboxyalkyl cellulose, polyvinyl pyrrolidone, N-vinyl-pyrrolidone - vinyl acetate copolymer, sugar alcohol or polyethylene glycol. |