http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0861245-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 |
| filingDate | 1996-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e0fb5b4225f5fa17d6a1e74e5fe4580 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6ebbbc35f3a8e599c65f44841c3c4c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf8db87fd67e94eddb2fafe86fa1ccb7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d93739b5ab79e3a579c19d6da88eaea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77d0b195088ef0505180e4d53ad290f9 |
| publicationDate | 1998-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0861245-A1 |
| titleOfInvention | Piperidine and tetrahydropyridine derivatives |
| abstract | A class of substituted piperidine and tetrahydropyridine derivatives, linked through the 4-position thereof via an alkylene chain to a fused bicyclic heteroaromatic moiety such as indolyl, and further substituted at the 1-position by an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl-alkyl, aryl-alkyl or heteroaryl-alkyl moiety, are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5-HT1Dα receptor subtype whilst processing at least a 10-fold selective affinity for the 5-HT1Dα receptor subtype relative to the 5-HT1Dβ subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists. |
| priorityDate | 1995-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1457.