| abstract |
Enantiomers of cis-Benz[e]indole compounds of formula (I), wherein R1 is hydrogen, C¿1-6?-alkyl, cycloalkylmethyl, allyl or alkenyl; R?4¿ is hydroxy, C¿1-6?-alkoxy, O-acyl, triflate or carbamoyl; and R?2, R3, R5¿ are the same or different and independently are hydrogen, halogen, trifluoromethyl or C¿1-6?-alkyl, are useful as selective dopamine-D3 receptor ligands in the treatment of central nervous system ailments related to dysfunction of the central dopamine system. |