| abstract |
This invention provides processes for producing quinolone compounds which comprise cultivating Amycolata sp. FERM BP-4785, and then isolating quinolone compounds from the fermentation broth. The compounds produced by these processes include compounds of formula (I) wherein R1 is H, R2 is (a) and R3 is CH¿3; R?1 is CH¿3, R?2 is (a) and R3 is CH¿3?; or R?1¿ is CH¿3, R?2 is (b) and R3 is CH¿3?; and the like. The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of diseases, disorders and adverse conditions caused by Helicobacter pylori and is particularly useful in the treatment of gastroduodenal disorders, diseases and adverse conditions caused thereby. |