| abstract |
An object of the present invention is to offer anpharmaceutical composition containing an extract fromninflammatory tissue inoculated with vaccinia virus having ansuppressing action to death of cells and an excessivenproduction of nitrogen monoxide induced by endotoxin and annimproving action to hypotension induced by endotoxin. n The present invention is a novel pharmaceuticalncomposition containing an extract from inflammatory tissueninoculated with vaccinia virus such as a nitrogen monoxidenproduction suppressor, a therapeutic agent for sepsis, annantiendotoxinic agent and a therapeutic agent for endotoxinnshock. n In sepsis and other serious bacterial infectiousndiseases, endotoxin (an intracellular toxin) is produced and anshock symptom is induced by its action. Accordingly, thensubstance of the present invention having an excellentninhibitory action to the endotoxin-induced toxicity asnmentioned above is quite useful for the treatment or thenprevention of endotoxin-induced shock symptom, sepsis andnvarious symptoms accompanied thereby. In addition, thensubstance of the present invention has an inhibitory action tonabnormal nitrogen monoxide production during the diseasednstate and, therefore, it is also useful as a therapeutic andnpreventive agent to the diseases wherein an excessive nitrogennmonoxide production is participated such as acute hypotension. |