| abstract |
Use of 11-phenyl steroid derivatives of formula (I) and their salts in hormone replacement therapy to treat the effects of the menopause or perimenopause. n = 2 or 3; R1, R2 = H or 1-4C alkyl; or NR1R2 = 5-15 membered optionally unsaturated, mono- or poly-cyclic heterocycle which may contain 1-3 further hetero atoms selected from O, N, S and which may be substituted; X = OH (optionally esterified); and Y = H, 2-4C alkenyl or 2-4C alkynyl; or X+Y = a group of formula (ii), (iii) or (iv); or X+Y = oxo. |