http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0849272-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f4dce064add4f464596348bea6de4c5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6512 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5532 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3873 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3808 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5765 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-576 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6512 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-38 |
| filingDate | 1993-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d043aac894e70c6406aae6eda35e047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1414e8fd784d106ba98b3a8c04c47986 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17c2430049e0d8a3e961ceefa71ff011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f790a7fd1b87ccb68fb36ef6fb61d7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf826819704be56eb95d51d3fc32b2a3 |
| publicationDate | 1998-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0849272-A1 |
| titleOfInvention | Quaternary nitrogen-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque |
| abstract | 1. Quaternary nitrogen-containing phosphonates which are usefulnin treating or prevening disorders of abnormal calcium andnphosphate metabolism and the pharmaceutically-acceptable saltsnand esters thereof, characterised in that they have the generalnstructure:n nwherein m and n are integers from 0 to 10; m + n is from 0 to 10;n (a) Q is a covalent bond or a moiety selected from O, S, NR 1 ; (b) Y is N+(R 8 ) 2 or C(R 1 ) 2 , and when Y is C(R 1 ) 2 , at leastnone R 2 must be N + (R 8 ) 3 ; (c) Z is a five-membered saturated, unsaturated, or aromatic,nmonocyclic carbocycle or heterocycle containing onenheteroatom, wherein the heteroatom is nitrogen, (d) R is COOH, SO 3 H,PO 3 H 2 or P(O)(OH)R 4, wherein R 4 isnalkyl of 1-8 carbon atoms, preferably PO 3 H 2 ; (e) each R 1 is selected from SR 6 ; R 9 SR 6 ; hydrogen, hydroxy;nC 1 -C 8 alkyl; -OR 3 ; -CO 2 R 3 ; -O 2 CR 3 ; -NR 3 2 ; -N(R 3 )C(O)R 3 ,n-C(O)N(R 3 ) 2 ; halogen; -C(O)R 3 ; arylalkyl; nitro; aryl, nand combinations thereof, preferably SR 6 , R 9 SR 6 ,nhydrogen, C 1 -C 8 alkyl, - NR 3 2 or CO 2 R 3 ; (f) each R 2 is one or more substituents on the Z moietynindependently selected from N + (R 8 ) 3 ; SR 6 ; R 9 SR 6 ;nhydrogen; C 1 -C 8 alkyl; -OR 3 ; -CO 2 R 3 ; -O 2 CR 3 ; -NR 3 2 ;-N(R 3 )C(O)R 3 ;n-C(O)N(R 3 ) 2 ; halogen; hydroxy; -C(O)R 3 ;narylalkyl; nitro; aryl, preferably N + (R 8 ) 3 , SR 6 , R 9 SR 6 ,nhydrogen, C 1 -C 8 alkyl; -NR 3 2 , -OR 3 , -CO 2 R 3 ; (g) each R 1 is independently selected from hydrogen, alkylnhaving from 1-8 carbon atoms, and R 9 SR 6 , preferablynhydrogen, R 9 SR 6 or C 1 -C 8 alkyl. (h) R 1 is selected from hydrogen; halogen; SR 6 ; R 9 SR 6 , amino;nhydroxy; and C 1 -C 8 alkyl, preferably hydrogen, SR 6 ;nR 9 SR 6 ; (i) each R 6 is independently selected from H; -C(O)R 7 ;-C(S)R 7 ;n-C(O)NR 7 2 ; -C(S)N(R 7 ) 2 ; -C(S)OR 7 ; -C(O)OR 7 ;nwherein R 7 is hydrogen or C 1 -C 8 alkyl, preferablynhydrogen, -C(O)R 7 , -C(S)R 7 ; (j ) each R 8 is independently selected from nil, alkyl having 1-35ncarbon atoms, phenyl, benzyl, or R 9 SR 6 ; preferablynalkyl having 1-35 carbon atoms; (k) R 9 is C 1 -C 8 alkyl. |
| priorityDate | 1992-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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