| abstract |
A pharmaceutical compound of the formula:n nin whichn A is carboxy, tetrazolyl, -SO 2 H, -SO 3 H, -OSO 3 H, -CONHOH, or -P(OH)OR', -PO(OH)OR', -OPO(OH)OR' where R' isnhydrogen, C 1-6 alkyl, C 2-6 alkenyl or optionallynsubstituted phenyl-C 1-6 alkyl, B is a bond, C 1-6 alkylene or C 2-6 alkenylene, R 1 is hydrogen, hydroxyl, halo or group of the formulanA-B-, X is C 1-6 alkylene, C 2-6 alkenylene, C 2-6 alkynylene or C 1-6 nalkylene linked through -O-, -S- or -NR"- to Y, where R"nis hydrogen or C 1-6 alkyl, and Y is (1) n nin which R 2 and R 3 are each halo, nitro, nitrile, C 1-6 nalkyl, C 2-6 alkenyl, C 2-6 alkynyl or optionally substitutednphenyl, m and n are each 0 to 3, Q is -O-, -S-, -SO-,n-SO 2 -, -CH=CH-, -(CH 2 ) p -,-CONR"'- or -NR"'CO-, where p isn0 to 3 and R"' is hydrogen or C 1-6 alkyl, and Z isn nor (2)n nin which R 2 , R 3 , m, n and Z are as defined above; provided that when Z isn X is C 1-6 alkylene, C 2-6 alkenylene or C 2-6 alkynylene; nand salts and esters thereof. |