| abstract |
lep polypeptides and DNA (RNA) encoding such lep and a procedure for producingnsuch polypeptides by recombinant techniques is disclosed. Also disclosed are methods fornutilizing such lep for the treatment of infection, particularly bacterial infections. Antagonistsnagainst such lep and their use as a therapeutic to treat infections, particularly bacterialninfections are also disclosed. Also disclosed are diagnostic assays for detecting diseasesnrelated to the presence of lep nucleic acid sequences and the polypeptides in a host. Alsondisclosed are diagnostic assays for detecting polynucleotides encoding leader peptidase andnfor detecting the polypeptide in a host. |