| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c999fee6428152a996011d506925c2d7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-757 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-757
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-93 |
| filingDate |
1997-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a80ec2d0a6b8340ed951cef2c38b0e19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9738254d4f41d90817c8ac2f391e94a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_462b61fa111163fd23c6edea94d2f229
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2ca61f3f8b183c80f8a4e765d523f2d |
| publicationDate |
1998-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0845454-A1 |
| titleOfInvention |
Method for the production of optically active cyclopropane derivatives |
| abstract |
A single enantiomer of N-benzyl-α-phenylethylamine is usednas a resolving agent for racemic 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylicnacid. The latter maynbe produced by adding an equivalent amount of an alkali to 3-oxa-2-oxobicyclo[3.1.0]cyclopropane-1-carboxylicnacid ester innsolution. Reaction of the amine and carboxylic acid takesnplace in a selected solvent, and the resulting diastereomernsalt which crystallises but may be filtered off. This may bensubsequently decomposed with an alkali, and the resolutionnagent extracted into an organic solvent and then recovered.nThereafter, the aqueous phase is adjusted to an acid pH, tonrecover 3-oxa-2-oxobicyclo[3.1.0]hexane-1-carboxylic acid esternat a high optical purity, through solvent extraction. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007088571-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007088571-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7968748-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102177132-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102177132-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0208208-A1 |
| priorityDate |
1996-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |