| abstract |
Compounds of formula (I):n n[wherein: R 1 is aryl; R 2 is hydrogen, alkyl, alkoxy,nhalogen or cyano; R 3 is a group of formulan-B-NR 4 R 5 , where R 4 and R 5 are independentlynhydrogen, alkyl or substituted alkyl or R 4 and R 5 ,ntogether with the nitrogen to which they are attached,nform a heterocycle, and B is alkylene or a group ofnformula -CH 2 CH(OR 6 )CH 2 -, where R 6 is hydrogen,nalkanoyl, substituted alkanoyl or arylcarbonyl, or angroup of formula -D-R 7 , where D is a single bond ornalkylene and R 7 is a heterocycle; and A is alkylene;nand pharmaceutically acceptable salts and estersnthereof] are useful for the treatment and prevention ofnpsychosis. |