| abstract |
The present invention provides, in its principal aspect, compounds of the general formula: when A is -NHCO-, -N(CH3)-CO-, -NHCH2-, -N(CH3)-CH2-, -CH=CH-, -COCH2-, CH2CH2-, -CH(OH)CH2- or -C 3BOND C-; X can be H, CH3, NH2, NH(CH3),N(CH3)2, OH, OCH3, SH, R2 is hydrogen or a methyl or ethyl group; R3 is hydrogen or a methyl or ethyl group; n is 0, 1, 2, 3, 4, 5 or 6; R1 is selected from the group consisting of (a) alkyl; (b) C3 to C8 cycloalkyl; (c) phenyl or substituted phenyl; (d) heteroocyclic; and (f) decahydronaphthalene or octahydroindane; and When R1 and X taken together denote a 5, 6 or 6, 6 saturated bicyclic ring structure, X can be NH, O, S, SO2, When X is constrained in a 5, 6 or 6, 6, saturated bicyclic ring structure, then for example, when X=NH, R1 and X taken together mean an octahydroindole ring structure directly attached to A. |