| abstract |
A novel process for preparing a 1,4 benzodioxane derivativenshown by the formula (1) which is a useful intermediatenof circulatory drugs and drugs for psychoneurosis, characterizednin sulfonating a phenoxypropanediol with a sulfonylnhalide, eliminating the protective group, and then cyclizingnthe sulfonated compound by treating with a base followed by,nif necessary, further sulfonation.n n In the above formula, R 1 is H, RSO 2 , R is alkyl, phenylnwhich may be substituted with alkyl, R 2 , R 3 , R 4 are H, halogen,nOH, nitro, cyano, formyl, COOH, alkoxycarbonyloxy, alkyl,nalkoxy, haloalkyl, N,N-dialkylamino, alkylcarbonyl, alkoxycarbonyl,nphenyl which may be substituted by alkyl, etc.22 |