| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d45f2cc0a7f8047b68d7e339f61ff56e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-003 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-46 |
| filingDate |
1996-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df3112342d02202291744ab5fab62324
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6750c4f6792bafaaf8e58ef073cbbe40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e85bb3d93fe6cb1d574edd5d7c67ed2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63875f7295579cff2e46afa0e450e473
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_879583a5b33908b470425618e8c057d9 |
| publicationDate |
1998-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0840736-A1 |
| titleOfInvention |
Improved synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
| abstract |
A method is disclosed for preparing novel PNA synthons having protecting groups capable of removal under mild conditions. The PNA synthons are prepared by coupling novel N-substituted nucleobase intermediates having carbamate protection of the exocyclic amino group of the heterocycle to an amino protected backbone or an amino protected backbone ester of the amino acid N-(2-aminoethyl)-glycine. By the method of this invention, the resultant PNA synthons can have orthogonal protection of the carbamate protected nucleobase and the amino protected backbone. The PNA synthons are useful in the synthesis of peptide nucleic acids (PNAs) and other oligomers such as PNA-DNA chimeras, and may be used in automated synthesizers. Novel compositions of matter are also disclosed. In addition, a guanine PNA synthon having selective carbamate protection of the exocyclic 2-amino group with the C6 carbonyl group unprotected is disclosed. |
| priorityDate |
1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |