| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a521cfa321c963978df8ae98a84056a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-33337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-329 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-333
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-332
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-329
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-32 |
| filingDate |
1997-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74d2bb5183cf774c0574495f2aad815f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3c2fe3a00dc4db845f47468466f1854
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8ee65c9c5a7cb8e1c4fe4b4408210a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f65e4f76f8d5cb3f57b766545bb0b5a7 |
| publicationDate |
1998-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0839850-A2 |
| titleOfInvention |
Process for producing a polyoxyalkylene derivative substituted with succinimidyl group |
| abstract |
A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at the ends with N-hydroxysuccinimide in an inert solvent in the presence of dicyclohexylcarbodiimide; dissolving the obtained reaction product in chloroform, in an amount by weight of chloroform being 0.5 to 10 times as much as an amount by weight of the polyoxyalkylene compound having carboxyl group at the ends; and crystallizing the polyoxyalkylene derivative substituted with succinimidyl group by adding an aliphatic hydrocarbon having 5 to 8 carbon atoms to a resultant solution, an amount by weight of the aliphatic hydrocarbon being 2 to 10 times as much as an amount by weight of chloroform. n Materials can be handled with safety in the process of the present application. A highly pure polyoxyalkylene derivative substituted with succinimidyl group which does not cause turbidity in an aqueous solution and has an excellent quality as a material for drugs can be produced. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10954425-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011143274-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019036264-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10870788-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019036277-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10988659-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10640696-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10876039-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11034880-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10676658-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10745606-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111032819-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10647903-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793762-B2 |
| priorityDate |
1996-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |