abstract |
Disclosed herein are substituted benzylurea derivatives represented by the following general formula (1):n wherein R 1 and R 2 are independently H, a halogen atom, or an alkyl or alkoxyl group, R 3 is a phenyl or heterocyclic group which may be substituted, n is an integer of 1-6, and R 4 is a phenyl group which may be substituted, or salts thereof, and medicines comprising such a derivative as an active ingredient. The derivatives or salts thereof strongly inhibit only ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis. |